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Hyponatremia & Hypernatremia

Patient's Sodium: mEq/L
Target Sodium: mEq/L
Rate of Na Correction: mEq/L/hr
Patient's Weight:
Patient is a:
Calculate using:

Correct for

IVF Rate:
IV Fluids:

Classic Formulas:


Total H2O deficit (L) = total body water x ( 1 -
desired Na+

serum Na+


Na+ requirement (mmol) = total body water x (desired Na+ - serum Na+ )
Rate of infusion (cc/hr) = 
Na+ requirement (mmol) x 1000

infusate Na+ (mmol/L) x time (hours)

Adrogue Formula

Change in serum Na+ =
(infusate Na+ + infusate K+) - serum Na+

total body water + 1
Infusate Infusate Na+
5% NaCl 855
3% NaCl 513
0.9% NaCl (NS) 154
Lactate Ringer's 130
0.45% NaCl ( NS) 77
0.2% NaCl ( NS) 34
5% Dextrose in water (D5W) 0

Total Body Water (in liters) :
Children 0.6 x weight
Women 0.5 x weight
Men 0.6 x weight
Elderly Women 0.45 x weight
Elderly Men 0.5 x weight

Insensible water losses = 500 - 1500 cc/day.
Fever increases insensible water losses by 10% per degree Celsius above 38°, or 100-150 cc/day increase per degree Celsius above 37°.

Adrogue, HJ; and Madias, NE. Primary Care: Hypernatremia. New England Journal of Medicine 2000; 342(20):1493-1499.
Adrogue, HJ; and Madias, NE. Primary Care: Hyponatremia. New England Journal of Medicine 2000; 342(21):1581-1589.


DISCLAIMER: All calculations must be confirmed before use. The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgement. Neither ValueMD nor any other party involved in the preparation or publication of this site shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.

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