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Vancomycin PK

Vancomycin & Aminoglycoside Pharmacokinetics

Patient Information:

Drug:
Calculation:
Drug Infusion Time:
Current Weight:
Admit Weight:
Gender:
Age: years
Serum Creatinine: mg/dL
Height:   inches
Vancomycin Clearance:

References

Young, Lloyd Y., and Koda-Kimble, Mary A. Applied Therapeutics: The Clinical Use of Drugs. 6th Edition. Vancouver: Applied Therapeutics, Inc., 1995.

Equations

Initial Bolus-Model Equations

Ideal Body Weight (IBW) = 50 kg + 2.3 x (ht - 60 inches)

Cpss max (mg/L) = 
Dose  ( e - kt )

Vd

( 1 - e - kt )

Cpss max (mg/L) = 
Dose  ( e - kt )

Vd

( 1 - e - kt )

Initial Short-Infusion Equations

Ideal Body Weight (IBW) = 50 kg + 2.3 x (ht - 60 inches)

Cpss max (mg/L) = 
Dose  ( 1 - e - ktin )   x  e - kt1

tin x Cl

( 1 - e - kt )

Cpss max (mg/L) = 
Dose  ( 1 - e - ktin )   x  e - kt2

tin x Cl

( 1 - e - kt )

Revision Bolus-Model Equations

Ideal Body Weight (IBW) = 50 kg + 2.3 x (ht - 60 inches)

kel = 
ln( 
dose / Vd + C (trough)

C (trough)
 )

t

Dose (mg) = 
Cpss x Vd x ( 1 - e - kt )

e - kt

Cpss max (mg/L) = 
Dose  ( e - kt )

Vd

( 1 - e - kt )

Cpss max (mg/L) = 
Dose  ( e - kt )

Vd

( 1 - e - kt )

Revision Short-Infusion Equations

Ideal Body Weight (IBW) = 50 kg + 2.3 x (ht - 60 inches)

kel = 
ln( 
Cpss (peak)

Cpss (trough)
 )

Dt

Cl (L/hr) = 
Dose  ( 1 - e - ktin )  x  e - kt

Cpss x tin

( 1 - e - kt )

Dose (mg) = 
Cpss x Cl x tin x ( 1 - e - kt )

( 1 - e - ktin) ( e - kt )

Cpss max (mg/L) = 
Dose  ( 1 - e - ktin )   x  e - kt1

tin x Cl

( 1 - e - kt )

Cpss min (mg/L) = 
Dose  ( 1 - e - ktin )   x  e - kt2

tin x Cl

( 1 - e - kt )


DISCLAIMER

DISCLAIMER: All calculations must be confirmed before use. The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgement. Neither ValueMD nor any other party involved in the preparation or publication of this site shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user's use of or reliance upon this material.


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