Close
Back HOME Menu
Close

Natural Killer Cells/RBC/Sperm

Thread: Natural Killer Cells/RBC/Sperm

Tags: None
  1. Can2carib said:

    Natural Killer Cells/RBC/Sperm

    Hello,

    Quick question...

    I was studying immunology and came across the natural killer cell. From my understanding, natural killer cells basically kill cells that lack MHC I (found on all nucleated cells and platelets). I guess my question is then why don't natural killer cells kill our own RBCs? What is the marker/surface antigen that prevents RBC destruction?

    In addition, I understand that the testes are an immunologically privileged area of the body; however, when sperm enter the female vaginal tract, why aren't natural killer cells activated by the lack of MHC on sperm?

    Hope these aren't stupid questions.....maybe I overlooked something totally obvious.
     
  2. whatsupdoc2012's Avatar

    whatsupdoc2012 said:
    Quote Originally Posted by Can2carib View Post
    Hello,

    Quick question...

    I was studying immunology and came across the natural killer cell. From my understanding, natural killer cells basically kill cells that lack MHC I (found on all nucleated cells and platelets). I guess my question is then why don't natural killer cells kill our own RBCs? What is the marker/surface antigen that prevents RBC destruction?

    In addition, I understand that the testes are an immunologically privileged area of the body; however, when sperm enter the female vaginal tract, why aren't natural killer cells activated by the lack of MHC on sperm?

    Hope these aren't stupid questions.....maybe I overlooked something totally obvious.
    The MHC class 1 molecule has to do with the HLA system.RBCs do not have this system.Also, the antigen which the NK cells attack is not clearly understood nor identified as yet. But in any case the RBCs do not contain this antigen either.

    Normally, the testes contain a natural barrier that acts as a protective layer by preventing immune cells from gaining access to sperm within the male reproductive tract. However, the barrier can be broken when testicles are physically injured, after a surgery (biopsy or vasectomy) or after a prostate gland infection. This allows sperm to come into contact with the immune system resulting in the production of the antibodies. If a high number of sperm antibodies come into contact with a manís sperm, it may be hard for the sperm to fertilize an egg.
     
  3. ethan11 said:

    Thumbs up

    WBC's are meant for repelling and fighting external intruding bodies. RBC's are there to take care of the hemoglobin and oxygen transport in human body. And as the name 'Natural killer cells' itself suggests, they kill defected (lacking MHC I) cells only. It's simple.
     
  4. Laz1 said:
    "Not well understood" and anything not well understood you dont have to learn :P
     
  5. ethan11 said:
    Means? Could you plz come again?
     
  6. goodnana said:
    Good article! Thank you for sharing!
     
  7. aanu621 said:
    hi, thank you for the explaination.
     
  8. viha said:
    From the understanding of NK cell function currently available, the acceptable hypothesis is that kill under a dominant activation. In other words, the activation signals from the activating receptors must dominate profoundly over the signals from the inhibitory receptors. However, the inhibitory signals hold the veto power. Hence, for NK cells to kill a target cell, signalling from the inhibitory receptors must be completely off. Therefore it is possible that low MHC Class I expressing cells are protected because they are able to turn on the inhibitory receptors on NK cells by expressing more of their ligands.
     
This website is not sponsored or endorsed by the USMLE, NBME or FSMB.
Search Engine Optimization by vBSEO ©2011, Crawlability, Inc.