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isotype , allotype , idiotype

Thread: isotype , allotype , idiotype

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  1. asmii said:

    isotype , allotype , idiotype

    Contrast these three: isotype , allotype , idiotype
     
  2. Asclepius1's Avatar

    Asclepius1 said:
    Isotype -The class of an antibody heavy or light chain, IgM ,IgE IgA are examplesof different isotypes

    Allotype -The genetically determined difference in a molecule between members of the same species.( ususally result from substitution of only one or two amino acids in the constant region usually of heavy or light chains)- No biological significance

    Idiotype-The individual ,unique differences between antibodies of different antigen-binding specificities. Idiotypes are determined by the structure of the variable regioons of antibodies.
     
  3. Ella said:

    Question

    Hi guys, I did a search for this topic and came across this old thread.

    I'm having a hard time applying this concept. I can memorize the definitions yes...but can anyone give me examples on how this concept has been asked on the boards?? Has it even been asked?? I'm sure if it's a HY point it must have been presented on ppl's exams before.

    If anyone has a sample question out there about this concept please let me know. Memorizing the definition is the easy part...but I want to learn how to apply this.

    Thanks!
     
  4. ULTRON's Avatar

    ULTRON said:
    Isotype: Present in ALL members of the same species (ALL humans); ie., same for all humans.

    Allotype: Present in members of the same family, same ethnic group, etc. Used for paternity testing.

    Idiotype: Different for each and every individual.

    ULTRON

    Quote Originally Posted by Ella View Post
    Hi guys, I did a search for this topic and came across this old thread.

    I'm having a hard time applying this concept. I can memorize the definitions yes...but can anyone give me examples on how this concept has been asked on the boards?? Has it even been asked?? I'm sure if it's a HY point it must have been presented on ppl's exams before.

    If anyone has a sample question out there about this concept please let me know. Memorizing the definition is the easy part...but I want to learn how to apply this.

    Thanks!
    221/227/CS Pass
     
  5. Drgabroomunda said:
    thanx ultron ...good..one..even i was confused..but nw..all good
     
  6. isma said:
    great application of the concepts... ultron))
     
  7. shansvmc said:
    thank u for the explanation
     
  8. repollitzer said:

    another explanation

    This is how I have interpreted these meanings for further clarification. Isotype is the certain class of antibody, ie. IgG, IgM, etc. Whereas Allotype is the variations among populations between (heavy chains) antibodies ie. IgG in myself vs my friend vs eastern european patient. And finally idiotype is the variations between antibodies in their antigen binding regions, like the IgG from me that binds tetanus toxin vs cholera, vs my friends ag binding region that binds cholera toxin, etc.
     
  9. Laz1 said:
    Iso = IG Type
    Allo = ANIMAL specific (Species specific)
    Idio = IDs PATHOGENS (Antigen Specific)
     
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