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ITP vs TTP

Thread: ITP vs TTP

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  1. BiscayneBlvd said:

    ITP vs TTP

    i know this is a very basic concept: ITP and TTP...but for some reason i'm having a hard time differentiating between the 2 of them. Does anybody have anything helpful to help me...


    Thanks
     
  2. md90's Avatar

    md90 said:
    i know this is a very basic concept: ITP and TTP...but for some reason i'm having a hard time differentiating between the 2 of them. Does anybody have anything helpful to help me...
    think vWF deficiency--one has it and the other does not--TTP does along with fever, renal failure, schistocytes, and CNS deficits...

    Is all that I can think of.. ITP (I=Idiopathic) which is unknown cause, and believe that it occurs more in children and type II hypersensitivity..
    "SLAM-DUNK THE STEPS"

    “Peace, it does not mean to be in a place where there is no noise, no trouble, or no hard work…..it means to be in the midst of those things and still be calm in your
    heart.”
     
  3. wcb22 said:

    itp

    just remember, with TTP you will see schistocytes, and it is generally more serious than ITP. TTP is, for all intents and purposes, HUS (hemolytic uremic syndrome) in kids.

    No schistocytes in ITP. It is associated with lupus, think autoimmune thrombocytopenia purpura. there are antibodies directed against the platelets.
    M.D., PGY-3 Internal Medicine
     
  4. WarEagleMD said:

    Ttp = fat rn

    I learned from my resident on internal medicine to remember "FAT RN" for diagnosing TTP:
    F- fever
    A- hemolytic anemia (schistocytes on smear)
    T- thrombocytopenia
    R- renal failure
    N- neuro dysfunction (confusion, stupor, altered mental status)
     
  5. shilpakary said:
    nice info
     
  6. sprtsmd12 said:
    nice one warmd, im gonna use that one
     
  7. offdan said:
    two basic differences, but it's better to know when you get to know the pathogenesis
     
  8. Yummy_Prosciutto said:
    ITP: Problem is limited to the lack of platelets/bleeding. Due to anti-platelet Abs and platelet destruction, esp in spleen.

    Thrombotic TP: Problem is microvasculature thrombosis causing end organ damage and hemolysis. The thrombosis causes a secondary, consumptive thrombocytopenia. Bleeding risks are of secondary significance compared to thrombotic end organ damage. Due to AB mediated, increased vWF activity or diffuse endothelial injury.

    Extra credit: End results similar to DIC. DIC is coag factor mediated thrombosis. TTP is platelet mediated. DIC has coag cascade abnormalities/lab values. TTP has normal coag factors, but the platelet plugs cause more hemolysis/schistocytes.
     
  9. usmle_by_k said:
    Isolated thrombocytopenia in ITP
     
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